What is Sovaldi 400mg (sofosbuvir)?
Sovaldi 400mg (sofosbuvir) is an HCV-fighting drug that must be used with other drugs. In the United States, Sovaldi is approved for people with hepatitis C genotypes 1, 2, 3, or 4 who are over 18 years old.
Sovaldi 400mg (sofosbuvir) works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.
How is Sovaldi 400mg (sofosbuvir) used?
Sovaldi 400mg (sofosbuvir) is taken once daily, with or without food, for 12 to 24 weeks. Some people will use Sovaldi with a drug called ribavirin (RBV), which is taken twice daily with food. The type and length of treatment depends on HCV genotype, treatment history, whether a person has cirrhosis, and the other drugs used with it.
Harvoni is a combination of Sovaldi and ledipasvir (see TAG’s Harvoni fact sheet for more information).
Sovaldi and Olysio—another HCV-fighting drug—have been approved for use in people over 18 years old who have HCV genotype 1 (see TAG’s Olysio fact sheet for more information).
Sovaldi and Daklinza—another HCV-fighting drug—have been approved for use in people over 18 years old who have HCV genotype 3 (see TAG’s Daklinza fact sheet for more information).
Side effects Sovaldi 400mg (sofosbuvir)
The most common side effects with Sovaldi in combination with ribavirin and peginterferon alfa were similar to those commonly reported with ribavirin or peginterferon alfa and included fatigue (tiredness), headache, nausea (feeling sick) and insomnia (difficulty sleeping). For the full list of side effects of Sovaldi, see the package leaflet.
Sovaldi must not be used together with certain types of medicines which can reduce the effects of Sovaldi. Such medicines include:
rifampicin and rifabutin (antibiotics);
St. John’s wort (a herbal preparation used to treat depression and anxiety);
carbamazepine, phenobarbital and phenytoin (medicines for epilepsy).
Interactions with other medications
Combining medications can increase or lower drug levels (called drug-drug interactions). Increasing drug levels can make side effects from each drug worse. If drug levels get too low, a drug can stop working, putting people at risk for drug resistance or not being cured.
Sovaldi should not be used with a medication called amiodarone because it can cause life-threatening heart problems.