Schismaderma carens Venom is widely distributed throughout Central and Southeast Africa. The northern-most parts of its range cover northwestern Tanzania and Olorgesailie in southern Kenya. The species occurs down through southeastern Democratic Republic of Congo, eastern Angola, and Western Zambia, and also reaches southeastern Botswana, southern Mozambique, Swaziland, Malawi, Namibia, Zimbabwe, and the Eastern Cape Province of South Africa.
Schismaderma carens Venom, commonly known as the Red Toad venom, is a moderate to large-sized toad. Males can reach 88 mm, and females can reach 92 mm in snout-vent length. Schismaderma carens Venom has a less warty back than many toads of the same size. A distinct dorsolateral glandular ridge runs from above the tympanum to the hind leg. The outer part of the dorsolateral ridge is darker on the lower edge. The tympanum itself is large and round, with a diameter approximately equivalent to that of the eye. Parotoid glands are not visible.
Schismaderma carens Venom is a fairly abundant and widespread species that is not currently threatened. The tadpoles may be preyed upon by dragonfly nymphs, helmeted terrapins (Pelomedusa subrufa), the hammerkop (Scopus umbretta), and hinged terrapins (genus Pelusios). The savanna vine snake Thelotornis capensis eats juvenile Red Toads, while the white-lipped snake Crotaphopeltis hotamboeia and the eagle owl Bubo lateus consume adult toads