Keytruda 100mg is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells.
Keytruda 100mg is a cancer medicine that interferes with the growth and spread of cancer cells in the body. It is an immunotherapy medication that helps shrink tumors and helps patients with advanced melanoma live longer.
What Keytruda 100mg Is Used For
Treatment of recurrent or metastatic cervical cancer in patients whose tumors express PD-L1 (combined positive score [CPS] ≥ 1), as determined by an approved test, and with disease progression on or after chemotherapy.
Treatment of recurrent locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma in patients whose tumors express PD-L1 (CPS ≥ 1), as determined by an approved test, with disease progression on or after two or more prior lines of therapy including fluoropyrimidine- and platinum-containing chemotherapy, and if appropriate, HER2/neu-targeted therapy.
For the treatment of unresectable or metastatic melanoma.
Patients with metastatic non-small cell lung cancer (NSCLC) whose tumors express PD-L1 as determined by an FDA-approved test and who have disease progression on or after platinum-containing chemotherapy.
For treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) with disease progression on or after platinum-containing chemotherapy.
Treatment of primary mediastinal large B-cell lymphoma (PMBCL) in adult or pediatric patients with refractory disease ow ho have relapsed after 2 or more prior lines of therapy.
For treatment of adult and pediatric patients with refractory classical Hodgkin lymphoma (cHL), or those who have relapsed after three or more prior lines of therapy.
For treatment of locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy.
Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.
How Keytruda 100mg is Given
Keytruda 100mg is given as an intravenous injection through a vein (IV) over 30 minutes every 3 weeks.
You may receive medications before the infusion to reduce allergic reactions.
The amount of pembrolizumab that you will receive depends on many factors, including your weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.
Side Effects Keytruda 100mg
Important things to remember about the side effects of pembrolizumab:
Most people do not experience all of the side effects listed.
Side effects are often predictable in terms of their onset and duration.
A few side effects can occur weeks or months after discontinuation of treatment.
There are many options to help manage and prevent worsening of side effects.
There is no relationship between the presence or severity of side effects and the effectiveness of the medication.
The following side effects are common (occurring in greater than 30%) for patients taking pembrolizumab:
These side effects are less common side effects (occurring in about 10-29%) of patients receiving pembrolizumab:
Increased liver enzymes
Pain in extremity
Shortness of breath
Upper respiratory tract infection
A serious, but uncommon side effect of pembrolizumab may be an immune-mediated reaction. When this side effect occurs, it affects primarily the bowels, liver, skin, nerves and the endocrine system. This immune reaction can occur during treatment but can also be seen weeks or months after discontinuation of treatment. Symptoms of this reaction will be monitored throughout treatment (diarrhea, rash, and neuropathy). Lab work will check for elevated liver enzymes and thyroid function.
Keytruda 100mg Interactions
This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient’s body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Other drugs may affect pembrolizumab, including prescription and over-the-counter medicines, vitamins, and herbal products.